可以利用font 设置。设置方法如下：
创新互联是一家专注于成都做网站、网站建设与策划设计,临朐网站建设哪家好?创新互联做网站,专注于网站建设十年,网设计领域的专业建站公司;建站业务涵盖:临朐等地区。临朐做网站价格咨询:18982081108
TextBox1.Font = New System.Drawing.Font("宋体", 10)
也可以通过字体对话框来实现 如：
Private Sub myButton_Click(sender As Object, e As EventArgs)
Dim myFontDialog As FontDialog
myFontDialog = New FontDialog()
If myFontDialog.ShowDialog() = DialogResult.OK Then
' Set the control's font.
myDateTimePicker.Font = myFontDialog.Font
End If
End Sub
能
我们写exe程序时，默认字体是宋体，比较难看，指定了其他字体，但是其他用户上没有你指定的这个字体的话，也会变成默认的宋体。解决的办法有这么几个：
1，叫用户安装相应字体，这个基本不可能实现，因为没有几个人会进行这样的操作；
2，给用户安装相应字体，这个办法可行，在制作安装包时将字体打包进去，然后用户安装程序的时候连字体也一并安装上去，一劳永逸；
3，把字体导入到程序资源中，让程序直接调用字体资源，缺点是导致程序体积巨大；
4，将字体文件放到程序目录里，在程序里单独调用。
个人觉得第4种办法比较方便，所以决定采用这种方法，把代码写出来给需要的同学。
引用：
Imports System.Drawing.Text
public sub Setfont()
dim AppPath as string = Application.StartupPath
try
dim font1 as PrivateFontCollection = new PrivateFontCollection()
font1.AddFontFile(AppPath + "\font\msyh.ttf") '字体的路径及名字
dim myFont as Font = new Font(font.Families[0].Name, 9,FontStyle.Regular,GraphicsUnit.Point, 134)
'设置窗体控件字体，哪些控件要更改都写到下面
label1.Font = myFont
label2.Font = myFont
label3.Font = myFont
button1.Font = myFont
button2.Font = myFont
button3.Font = myFont
button4.Font = myFont
button5.Font = myFont
catch e as exception
MessageBox.Show("字体不存在或加载失败\n程序将以默认字体显示", "警告",
MessageBoxButtons.OK, MessageBoxIcon.Exclamation);
end try
然后在public sub Form1()
InitializeComponent()
Setfont() '启动字体设置函数
end sub
Me.RichTextBox1.SelectionFont = New Font("宋体", 14.25!, FontStyle.Bold Or FontStyle.Italic)
给点提示吧，已粗体为例（完全是我自己的方法，不知别人是怎么做的）：
'先获取选择的字体信息（字体、大小、样式。。。）
Dim currentFont As System.Drawing.Font = RichTextBox1.SelectionFont
'在重新定义某种样式的时候，不丢失其他信息
RichTextBox1.SelectionFont = New Font(currentFont.FontFamily, currentFont.Size, FontStyle.Bold)
'新建一个VB.NET 项目，把原来所有代码删了，把下面的代码复制贴上去解OK了
Public Class Form1
Inherits System.Windows.Forms.Form
#Region " Windows 窗体设计器生成的代码 "
Public Sub New()
MyBase.New()
'该调用是 Windows 窗体设计器所必需的。
InitializeComponent()
'在 InitializeComponent() 调用之后添加任何初始化
End Sub
'窗体重写 dispose 以清理组件列表。
Protected Overloads Overrides Sub Dispose(ByVal disposing As Boolean)
If disposing Then
If Not (components Is Nothing) Then
components.Dispose()
End If
End If
MyBase.Dispose(disposing)
End Sub
'Windows 窗体设计器所必需的
Private components As System.ComponentModel.IContainer
'注意: 以下过程是 Windows 窗体设计器所必需的
'可以使用 Windows 窗体设计器修改此过程。
'不要使用代码编辑器修改它。
Friend WithEvents RadioButton1 As System.Windows.Forms.RadioButton
Friend WithEvents RadioButton2 As System.Windows.Forms.RadioButton
Friend WithEvents GroupBox1 As System.Windows.Forms.GroupBox
Friend WithEvents GroupBox2 As System.Windows.Forms.GroupBox
Friend WithEvents RadioButton3 As System.Windows.Forms.RadioButton
Friend WithEvents RadioButton4 As System.Windows.Forms.RadioButton
Friend WithEvents CheckBox1 As System.Windows.Forms.CheckBox
Friend WithEvents CheckBox2 As System.Windows.Forms.CheckBox
Friend WithEvents CheckBox3 As System.Windows.Forms.CheckBox
Friend WithEvents TextBox1 As System.Windows.Forms.TextBox
Friend WithEvents Button1 As System.Windows.Forms.Button
System.Diagnostics.DebuggerStepThrough() Private Sub InitializeComponent()
Me.RadioButton1 = New System.Windows.Forms.RadioButton
Me.RadioButton2 = New System.Windows.Forms.RadioButton
Me.GroupBox1 = New System.Windows.Forms.GroupBox
Me.GroupBox2 = New System.Windows.Forms.GroupBox
Me.RadioButton3 = New System.Windows.Forms.RadioButton
Me.RadioButton4 = New System.Windows.Forms.RadioButton
Me.CheckBox1 = New System.Windows.Forms.CheckBox
Me.CheckBox2 = New System.Windows.Forms.CheckBox
Me.CheckBox3 = New System.Windows.Forms.CheckBox
Me.TextBox1 = New System.Windows.Forms.TextBox
Me.Button1 = New System.Windows.Forms.Button
Me.GroupBox1.SuspendLayout()
Me.GroupBox2.SuspendLayout()
Me.SuspendLayout()
'
'RadioButton1
'
Me.RadioButton1.Location = New System.Drawing.Point(16, 24)
Me.RadioButton1.Name = "RadioButton1"
Me.RadioButton1.Size = New System.Drawing.Size(56, 24)
Me.RadioButton1.TabIndex = 1
Me.RadioButton1.Text = "红色"
'
'RadioButton2
'
Me.RadioButton2.Location = New System.Drawing.Point(72, 24)
Me.RadioButton2.Name = "RadioButton2"
Me.RadioButton2.Size = New System.Drawing.Size(48, 24)
Me.RadioButton2.TabIndex = 2
Me.RadioButton2.Text = "蓝色"
'
'GroupBox1
'
Me.GroupBox1.Controls.Add(Me.RadioButton2)
Me.GroupBox1.Controls.Add(Me.RadioButton1)
Me.GroupBox1.Location = New System.Drawing.Point(16, 144)
Me.GroupBox1.Name = "GroupBox1"
Me.GroupBox1.Size = New System.Drawing.Size(128, 56)
Me.GroupBox1.TabIndex = 5
Me.GroupBox1.TabStop = False
Me.GroupBox1.Text = "颜色"
'
'GroupBox2
'
Me.GroupBox2.Controls.Add(Me.RadioButton3)
Me.GroupBox2.Controls.Add(Me.RadioButton4)
Me.GroupBox2.Location = New System.Drawing.Point(176, 144)
Me.GroupBox2.Name = "GroupBox2"
Me.GroupBox2.Size = New System.Drawing.Size(136, 56)
Me.GroupBox2.TabIndex = 6
Me.GroupBox2.TabStop = False
Me.GroupBox2.Text = "字号"
'
'RadioButton3
'
Me.RadioButton3.Location = New System.Drawing.Point(16, 24)
Me.RadioButton3.Name = "RadioButton3"
Me.RadioButton3.Size = New System.Drawing.Size(56, 24)
Me.RadioButton3.TabIndex = 2
Me.RadioButton3.Text = "30号"
'
'RadioButton4
'
Me.RadioButton4.Location = New System.Drawing.Point(72, 24)
Me.RadioButton4.Name = "RadioButton4"
Me.RadioButton4.Size = New System.Drawing.Size(48, 24)
Me.RadioButton4.TabIndex = 1
Me.RadioButton4.Text = "40号"
'
'CheckBox1
'
Me.CheckBox1.Location = New System.Drawing.Point(32, 208)
Me.CheckBox1.Name = "CheckBox1"
Me.CheckBox1.Size = New System.Drawing.Size(80, 32)
Me.CheckBox1.TabIndex = 7
Me.CheckBox1.Text = "加粗"
'
'CheckBox2
'
Me.CheckBox2.Location = New System.Drawing.Point(120, 208)
Me.CheckBox2.Name = "CheckBox2"
Me.CheckBox2.Size = New System.Drawing.Size(80, 32)
Me.CheckBox2.TabIndex = 8
Me.CheckBox2.Text = "斜体"
'
'CheckBox3
'
Me.CheckBox3.Location = New System.Drawing.Point(200, 208)
Me.CheckBox3.Name = "CheckBox3"
Me.CheckBox3.Size = New System.Drawing.Size(80, 32)
Me.CheckBox3.TabIndex = 9
Me.CheckBox3.Text = "下划线"
'
'TextBox1
'
Me.TextBox1.Font = New System.Drawing.Font("宋体", 9.0!, System.Drawing.FontStyle.Regular, System.Drawing.GraphicsUnit.Point, CType(134, Byte))
Me.TextBox1.Location = New System.Drawing.Point(8, 16)
Me.TextBox1.Multiline = True
Me.TextBox1.Name = "TextBox1"
Me.TextBox1.ScrollBars = System.Windows.Forms.ScrollBars.Vertical
Me.TextBox1.Size = New System.Drawing.Size(320, 112)
Me.TextBox1.TabIndex = 0
Me.TextBox1.Text = "话说天下大势，分久必合，合久必分。"
'
'Button1
'
Me.Button1.Location = New System.Drawing.Point(88, 256)
Me.Button1.Name = "Button1"
Me.Button1.Size = New System.Drawing.Size(152, 32)
Me.Button1.TabIndex = 10
Me.Button1.Text = "确定"
'
'Form1
'
Me.AutoScaleBaseSize = New System.Drawing.Size(6, 14)
Me.ClientSize = New System.Drawing.Size(336, 310)
Me.Controls.Add(Me.Button1)
Me.Controls.Add(Me.CheckBox3)
Me.Controls.Add(Me.CheckBox2)
Me.Controls.Add(Me.CheckBox1)
Me.Controls.Add(Me.GroupBox2)
Me.Controls.Add(Me.GroupBox1)
Me.Controls.Add(Me.TextBox1)
Me.Name = "Form1"
Me.StartPosition = System.Windows.Forms.FormStartPosition.CenterScreen
Me.Text = "Form1"
Me.GroupBox1.ResumeLayout(False)
Me.GroupBox2.ResumeLayout(False)
Me.ResumeLayout(False)
End Sub
#End Region
Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
If Me.RadioButton1.Checked = True Then Me.TextBox1.ForeColor = System.Drawing.Color.Red
If Me.RadioButton2.Checked = True Then Me.TextBox1.ForeColor = System.Drawing.Color.Blue
If Me.RadioButton3.Checked = True Then Me.TextBox1.Font = New Font("宋体", 30)
If Me.RadioButton4.Checked = True Then Me.TextBox1.Font = New Font("宋体", 40)
Dim style As FontStyle = FontStyle.Regular
If Me.CheckBox1.Checked = True Then style = style Or FontStyle.Bold
If Me.CheckBox2.Checked = True Then style = style Or FontStyle.Italic
' If Me.CheckBox1.Checked = True And Me.CheckBox2.Checked = True Then TextBox1.Font = New Font(TextBox1.Font, FontStyle.Bold Or FontStyle.Italic)
If Me.CheckBox3.Checked = True Then style = style Or FontStyle.Underline
Me.TextBox1.Font = New Font(TextBox1.Font, style)
End Sub
End Class