两种方法：
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1. 用WithEvents声明变量，这样你就可以像对待拖上去的控件一样操作：
Public Class Form3
WithEvents btn As New Button
Private Sub Form3_Load(sender As Object, e As EventArgs) Handles Me.Load
Controls.Add(btn)
End Sub
Private Sub btn_Click(sender As Object, e As EventArgs) Handles btn.Click
MsgBox(Now)
End Sub
End Class
2. 使用AddHandler 语句：
Public Class Form3
Private Sub Form3_Load(sender As Object, e As EventArgs) Handles Me.Load
Dim btn As New Button
AddHandler btn.Click, AddressOf btn_Click
Controls.Add(btn)
End Sub
Private Sub btn_Click(sender As Object, e As EventArgs)
MsgBox(Now)
End Sub
End Class
WithEvents (Visual Basic)：
AddHandler 语句：
动态生成的控件：
Private Sub UserControl1_Load(sender As System.Object, e As System.EventArgs) Handles MyBase.Load
Dim myPicture = New System.Windows.Forms.PictureBox()
Me.Panel3.Controls.Add(myPicture)
myPicture.Size = New System.Drawing.Size(115, 160)
myPicture.TabStop = False
myPicture.Name = "p"
myPicture.Cursor = Cursors.Hand
AddHandler myPicture.Click, AddressOf mypic_Click '添加事件
End Sub
处理事件的过程：
Private Sub mypic_Click() 'ByVal id As String
Dim bookInfo As New BookInfo
bookInfo.Show()
Me.Parent.Enabled = False
'把图片的声明放在外面，类里面过程外面，而且要用As，不然等会儿没法用
Dim myPicture As New System.Windows.Forms.PictureBox()
'动态生成的控件，加一行
Private Sub UserControl1_Load(sender As System.Object, e As System.EventArgs) Handles MyBase.Load
Me.Panel3.Controls.Add(myPicture)
myPicture.Size =New System.Drawing.Size(115, 160)
myPicture.TabStop =False
myPicture.Name ="p"
myPicture.Cursor = Cursors.Hand
AddHandler myPicture.Click, AddressOf mypic_Click '添加事件
AddHandler returnid, AddressOf idReturned '绑定事件和过程
End Sub
'再来个事件，放在声明的地方，就是类里面、过程外面
Private Event returnid(ByVal id As String) '这个事件可以传递值哦~
'普通的单击事件
Private Sub mypic_Click()
RaiseEvent returnid(myPicture.Name)
End Sub
'会传值的事件过程
Private Sub idReturned(ByVal id As String)
Dim bookInfo As New BookInfo
bookInfo.Show()
Me.Parent.Enabled = False
'用id变量做点什么吧
End Sub
如果要改事件的签名（参数一类的）的话，得重写控件。你可以这样自己弄一个事件。