本来有个属性FlatStyle设置为Popup基本上能实现这个情况，怎奈有个线框怎么也弄不掉。FlatAppearance.BorderSize设置为0不起作用，只对Flat有用，所以用代码在Flat和Popup两种风格之间切换。
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'在鼠标进入时设置为浮雕风格
Private Sub Button1_MouseEnter(ByVal sender As Object, ByVal e As System.EventArgs) Handles Button1.MouseEnter
Button1.FlatStyle = FlatStyle.Popup
End Sub
'离开时设置为平面风格，这样像标签一样只剩下文字，当然要FlatAppearance.BorderSize设置为0
Private Sub Button1_MouseLeave(ByVal sender As Object, ByVal e As System.EventArgs) Handles Button1.MouseLeave
Button1.FlatStyle = FlatStyle.Flat
End Sub
'另外把UseVisualStyleBackColor 设置为 False也会好看一点。
这个好办！！在form1 keydown事件中输入if e.keycode=keys.F1 then
加语句即可!!
新建一个Form1把Form1的KeyPreview改成True
拖入一个Button1到Form1上面
然后加入以下代码
Private Sub Form1_KeyDown(sender As Object, e As KeyEventArgs) Handles Me.KeyDown
If e.KeyData = (Keys.Alt Or Keys.G) Then
Button1.PerformClick() '或者用Button1_Click(Nothing, New EventArgs)
'快捷键Alt+G触发Button1_Click()事件。
End If
End Sub
Private Sub Button1_Click(sender As Object, e As EventArgs) Handles Button1.Click
Button1.Size = New Size(180, 23)
Button1.Text = "我被局部快捷键给召唤了~"
End Sub
ToolStripMenuItem.ShortcutKeys 属性
获取或设置与 ToolStripMenuItem 关联的快捷键。
使用 ShortcutKeys 属性可以将组合键分配给菜单命令，例如，将 Ctrl+C 分配给“复制”命令。 您可以使用快捷键而不使用访问键，也可以同时使用快捷键和访问键，访问键是菜单或菜单项中与 Alt 键一起使用的带下划线的字母。 通过在要用于访问键的字母前面键入一个“and”符 ()，可以在代码中定义访问键。
用API函数，以下代码Private Declare Function GetWindowLong Lib "user32" Alias "GetWindowLongA" (ByVal hwnd As Long, ByVal nIndex As Long) As LongPrivate Declare Function SetWindowLong Lib "user32" Alias "SetWindowLongA" (ByVal hwnd As Long, ByVal nIndex As Long, ByVal dwNewLong As Long) As Long
Private Declare Function SetLayeredWindowAttributes Lib "user32" (ByVal hwnd As Long, ByVal crKey As Long, ByVal bAlpha As Byte, ByVal dwFlags As Long) As LongPrivate Const WS_EX_LAYERED = H80000
Private Const GWL_EXSTYLE = (-20)
Private Const LWA_ALPHA = H2
Private Const LWA_COLORKEY = H1Private Declare Function SetWindowPos Lib "user32" (ByVal hwnd As Long, ByVal hWndInsertAfter As Long, ByVal X As Long, ByVal Y As Long, ByVal cx As Long, ByVal cy As Long, ByVal wFlags As Long) As Long
Private Const HWND_TOPMosT = -1
Private Const SWP_NOMOVE = H2
Private Const SWP_NosIZE = H1
Private Declare Function GetForegroundWindow Lib "user32" () As Long
Private Declare Function PostMessage Lib "user32" Alias "PostMessageA" (ByVal hwnd As Long, ByVal wMsg As Long, ByVal wParam As Long, lParam As Any) As Long
Const WM_KEYDOWN = H100
Const WM_KEYUP = H101
Const WM_CHAR = H102
Const VK_F1 = H70
Private Sub SendF1(hwnd) '调用这个过程即可对目标窗体发送F1键
Call PostMessage(hwnd, WM_KEYDOWN, VK_F1, 0)
Call PostMessage(hwnd, WM_KEYUP, VK_F1, 0)
End Sub这里是发送F1的实例，各个按键对应的虚拟键码，要到网上查